The trigger condition is always going to measure against some specific value. There is no way I can think of to trigger based on some unknown change to a particular set of columns unless you are storing the previous values in a parallel field. In that case you could do a trigger condition that would only fire if that columns value doesn't equal the parallel current value. You could then do the same for multiple columns. But each column would need a parallel column. Then when the flow does run the last thing you do is store the current values for those columns in the parallel fields.
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Paul Papanek Stork, MVP
Blog: https://www.dontpapanic.com/blog